Myelin basic protein also known as MBP is a protein which is responsible for the process of myelination of nerves in which a fatty substance gets collected around the nerve cell. A multi-layered membrane called myelin sheath functions as an insulator to increase the speed of conduction of axonal impulse. This membrane is unique to the nervous system.
MBP is responsible for maintaining the structure of myelin, the interaction of lipids presents in the myelin membrane. In humans, the MBP is present on chromosome no. 18. It is the protein that is local to the CNS and to other cells of the hematopoietic lineage. You can buy a high-quality Anti-Myelin basic protein antibody kit to perform the test.
It has other functions like interaction with a number of polynomic proteins like actin, tubulin, etc. MBP is responsible for the linkage of the cytosolic surfaces of multilayered compact myelin. It can act as a membrane linking protein that allows it to participate in the transmission of extracellular signals to the cytoskeleton in the tight points of myelin.
Some small-sized MBP is transferred into the nucleus and they form polynucleotides. Extracellular signals are then, received by myelin that cause changes in the phosphorylation of MBP. It suggests that MBP is also playing a part in signaling. Further study has revealed that this protein can be utilized by the myelin for different purposes.
So, anti-myelin basic protein antibody is an antibody that is used for the detection of the basic protein in the given sample. The smaller isoforms of MBP might have an important role to play in the process of remyelination of nerve cell axons in multiple sclerosis.